Abstract #4418

High Resolution Tomographic Imaging with a 6.3 T/m Field Free Line Magnetic Particle Imager

Elaine Yu¹, Bo Zheng¹, Zhi Wei Tay¹, Paul Keselman¹, Xinyi Y Zhou¹, Ryan Orendorff¹, Daniel W Hensley¹, R Matthew Ferguson², Amit P Khandhar², Scott J Kemp², Kannan M Krishnan^2,3, Patrick Goodwill^1,4, and Steven Conolly^1,5

¹Department of Bioengineering, University of California, Berkeley, CA, United States, ²Lodespin Labs, Seattle, WA, United States, ³Department of Material Science and Engineering, University of Washington, Seattle, WA, United States, ⁴Magnetic Insight, Inc., Alameda, CA, United States, ⁵Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, United States

Magnetic Particle Imaging (MPI) is a novel, high-contrast, and quantitative imaging modality that directly detects superparamagnetic iron oxide nanoparticle (SPIO) tracers. In MPI, the imaging sensitive region is a field free region produced by a strong gradient selection field. There are two imaging formats in MPI: Field Free Point (FFP) and Field Free Line (FFL). The spatial resolution of our previous FFL imager was limited by the strength of the FFL gradient (2.35 T/m). Here we describe the hardware development of a high resolution 6.3 T/m FFL MPI system using water-cooled electromagnets and a laminated iron-core.

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