Abstract #4375

Quantitative T2 values for Detection and Grading of Prostate Cancer

Tobias Franiel¹, Julia Mai¹, Mohamed Abubrig², Thomas Lehmann³, Felix Güttler¹, Elisabeth Weiland⁴, Tom Hilbert⁴, René Aschenbach¹, Friedrich-Carl von Rundstedt⁵, Marc-Oliver Grimm⁵, and Ulf Teichgräber¹

¹Department of Radiology, University Hospital Jena, Jena, Germany, ²Department of Pathology, Universitiy Hospital Jena, Jena, Germany, ³Department of Statistics, University Hospital Jena, Jena, Germany, ⁴Siemens Healthcare AG, Erlangen, Germany, ⁵Department of Urology, University Hospital Jena, Jena, Germany

Purpose: Determination of quantitative T2 values in prostate tissue and their evaluation for detection and grading of prostate cancer.

Methods: 3T T2 maps and ADC maps of 75 patients with 857 prostate areas (378x normal, 177x cancer, 150x BPH, 119x prostatitis and 33x precancer) were determined.

Results: T2 values differed significantly between cancer and normal (AUC=0.871), between cancer and BPH (AUC=0.827) and between cancer with GleasonScore 6 and ≥ 7 (AUC=0.742). T2 relaxivities decreased with increasing GleasonScore and correlated significantly with ADC-values (r=0.772).

Conclusion: T2 values seem to be adequate for the differentiation between prostate cancer and normal tissue or BPH.

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