Abstract #4360

Multi- and Sigle Parametric Approaches using Chemical Exchange Saturation Transfer (CEST) Imaging, Diffusion-Weighted Imaging and FDG-PET/CT for Pulmonary Nodule Diagnosis

Yoshiharu Ohno^1,2, Masao Yui³, Mitsue Miyazaki⁴, Yuji Kishida⁵, Shinichiro Seki^1,2, Katsusuke Kyotani⁶, and Takeshi Yoshikawa^1,2

¹Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan, ²Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Japan, ³Toshiba Medical Systems Corporation, Otawara, Japan, ⁴Radiology, UC, San Diego, La Jolla, CA, United States, ⁵Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁶Center for Radiology and Radiation Oncology, Kobe University Hospital, Kobe, Japan

No major reports have been reported the capability for differentiating malignant and benign pulmonary lesions among multi- and single parametric approaches by CEST imaging, DWI and PET/CT. We hypothesized that multi parametric approach by all three techniques had better potential for diagnosis of pulmonary nodule than single parametric approach, when applied with CEST imaging, DWI and FDG-PET/CT. The purpose of this study was to directly and prospectively compare the capability for differentiating of malignant from benign pulmonary nodules between multi- and single-parametric approaches by CEST, DWI, and FDG-PET/CT.

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