Abstract #4320

Repeatability of 3D MR Fingerprinting Measurements in Normal Breast Tissue

Ananya Panda¹, Yong Chen², Satyam Ghodasara³, Katherine Wright¹, Nicole Seiberlich^4,5, Mark Alan Griswold^1,4,5, and Vikas Gulani^1,4,5

¹Radiology, Case Western Reserve University, Cleveland, OH, United States, ²Radiology, University of North Carolina, Chapel Hill, NC, United States, ³Case Western School of Medicine, Cleveland, OH, United States, ⁴Radiology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States, ⁵Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

3D Breast Magnetic Resonance Fingerprinting (MRF) allows simultaneous breast tissue T₁ and T₂ mapping. In this study, same session repeatability of 3D MRF technique in normal breast tissue was evaluated (test/retest 10 minutes apart) and in two consecutive visits. The within subject coefficient of variance (wCV) for two visit scans was < 6% for T₁ and < 5% for T₂. The wCV for test-retest scan for T₁ was <5% and for T₂ was 6.5%. One-week repeatability of 3D MRF was good for both T₁ and T₂ (ICC T₁: 0.81 T₂: 0.88 at second visit). These variations are smaller than observed inter-subject variability. Thus breast MRF may be useful for longitudinal patient follow-up.

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