Abstract #4242

Optimized parameters for MP2RAGE images on 7-T MRI

Uksu Choi^1,2, Hirokazu Kawaguchi³, Yuichiro Matsuoka^1,2, Tobias Kober^4,5,6, and Ikuhiro Kida^1,2

¹Center for Information and Neural Networks, National Institute of Information and Communications Technology, Osaka, Japan, ²Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan, ³Siemens Healthcare K.K., Osaka, Japan, ⁴Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁵Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, ⁶LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

The MP2RAGE sequence at ultra-high magnetic fields can be advantageous for investigation of microstructural changes because of reduced B1 inhomogeneity and images with different contrasts (uniform (UNI), T1, and fluid and white matter suppression (FLAWS)). In this study, we used several evaluative methods to optimize the inversion times and flip angles for UNI, T1, and FLAWS images of the MP2RAGE sequence at 7 T. We found the optimized inversion times with flip angles for UNI and T1 images, but different parameters for FLAWS images. The results suggested that different parameters of MP2RAGE at 7 T should be applied for different contrast types.

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