Abstract #4192

Absence of T1 hyperintensity in the brain of high-risk iron loaded thalassemia patients after multiple administrations of high dose Gadobutrol

Antonella Meloni¹, Domenico Montanaro¹, Vincenzo Positano¹, Daniele De Marchi¹, Mariachiara Resta², Petra Keilberg¹, Laura Pistoia¹, Anna Spasiano³, Tommaso Casini⁴, Caterina Cinzia De Bari⁵, Sara De Cori¹, and Alessia Pepe¹

¹Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, ²Policlinico Università di Bari, Bari, Italy, ³Azienda Ospedaliera di Rilievo Nazionale "A. Cardarelli", Napoli, Italy, ⁴Ospedale “Meyer”, Firenze, Italy, ⁵Ospedale "San Donato", Arezzo, Italy

Our study describes the lack of increased signal intensity (SI) in T1-weighted MRI images after repeated administrations of Gadobutrol in a high-risk population (high dose/scan, iron overload that facilitates the transmetallation of gadolinium). A potential role of the chelation therapy cannot be excluded. Moreover, it is highlighted that SI ratios in the sampled areas differ between 1.5T and 3T.

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