Abstract #4157

Transcatheter intra-arterial perfusion (TRIP)-MRI for the evaluation of immediate Irreversible Electroporation effects in the VX2 rabbit liver tumor model.

Matteo Figini¹, Kang Zhou^1,2, Liang Pan^1,3, Junjie Shangguan¹, Chong Sun^1,4, Bin Wang^1,5, Na Shang¹, Quanhong Ma¹, Daniele Procissi¹, Andrew Christian Larson¹, and Zhuoli Zhang¹

¹Radiology, Northwestern University, Chicago, IL, United States, ²Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China, ³Radiology, The Third Affiliated Hospital of Soochow University, Changzhou, China, ⁴Orthopedics, Qilu Hospital, Shandong University, Jinan, China, ⁵General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China

Six rabbits with liver tumors underwent anatomical and perfusion MRI immediately after irreversible electroporation (IRE) treatment of the tumors, using a catheter inserted in the left hepatic artery to deliver the contrast agent (TRIP-MRI). All the treated regions showed low perfusion as measured by the Area under the tissue response Curve. In some cases, a rim or a few spots with higher AUC were present, and were presumably associated with the penumbra of reversible electroporation that is known to be present in IRE-treated tissues. TRIP-MRI could be a valuable non-invasive tool to assess IRE effect and to immediately plan retreatment.

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