Abstract #4050

Optical tracking-guided MR-ARFI for targeting focused ultrasound neuromodulation

Sumeeth V Jonathan^1,2, M Anthony Phipps^2,3, Vandiver L Chaplin^2,3, Aparna Singh^1,2, Pai-Feng Yang^2,4, Allen T Newton^2,4, John C Gore^1,2,4,5,6, Li Min Chen^2,4, Charles F Caskey^2,4, and William A Grissom^1,2,4,7

¹Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ²Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ³Chemical and Physical Biology, Vanderbilt University, Nashville, TN, United States, ⁴Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ⁵Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, United States, ⁶Physics and Astronomy, Vanderbilt University, Nashville, TN, United States, ⁷Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States

Magnetic resonance-acoustic radiation force imaging (MR-ARFI) pulse sequences permit localization and targeting during focused ultrasound (FUS) therapy. MR-ARFI uses motion-encoding gradients (MEGs) to visualize the tissue displacement caused by the acoustic beam’s radiation force. However, a priori knowledge of the acoustic beam’s position and orientation in space is critical for MR-ARFI so that the MEGs can be placed in the proper orientation. We used an optical tracking system to inform the geometry of MR-ARFI acquisitions. The proposed methods will be used to guide ongoing experiments that use MR-ARFI to produce acoustic beam maps for targeting ultrasound neuromodulation in real-time.

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