Abstract #4008

Study of Altered Urinary Metabolism in Prostate Cancer Patients using NMR Metabolomics

Pradeep Kumar¹, Rajeev Kumar², Virendra Kumar³, Senthil S Kumaran¹, Sanjay Thulkar⁴, Siddhartha D Gupta⁵, and Naranamangalam R Jagannathan⁶

¹Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, India, New Delhi, India, ²Department of Urology, All India Institute of Medical Sciences, New Delhi, India, New Delhi, India, ³Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, India, New Delhi, India, ⁴Department of Radiology, All India Institute of Medical Sciences, New Delhi, India, New Delhi, India, ⁵Department of Pathology, All India Institute of Medical Sciences, New Delhi, India, ⁶Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, India

The present study demonstrated the metabolic profile of urine samples of prostate cancer (PCa) patients (n=33) and healthy controls (HC; n=21) using 700 MHz high-resolution proton NMR for early diagnosis and to define noninvasive biomarker/s. A significantly lower concentration of leucine, histidine, tyrosine, citrate, dimethylglycine, glycerophosphocholine, choline, creatinine, indoxyl sulphate and formate was seen in PCa patients. These findings suggest metabolic alterations due to mitochondrial dysfunction, cell proliferation, energy demand, oxidative stress and protein turnover in PCa patients.

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