Abstract #4001

Detection of 5-Fluorouracil (5-FU) Tumor Trapping Using Fluorine-19 Chemical Shift Imaging in a Murine Model of Colorectal Cancer

Yurii Shepelytskyi¹, Karen Davenport², Matthew S Fox³, Tao Li², Mitchell Albert^1,2,4, and Eric Davenport⁵

¹Chemistry, Lakehead University, Thunder Bay, ON, Canada, ²Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada, ³Medical Biophysics, University of Western Ontario, London, ON, Canada, ⁴Northern Ontario School of Medicine, Thunder Bay, ON, Canada, ⁵Thunder Bay Regional Health Science Centre, Thunder Bay, ON, Canada

Colorectal cancer is an increasing healthcare problem and is the third leading cause of cancer deaths worldwide. Fluorine-19 (¹⁹F) chemical shift imaging (CSI) can detect the distribution of 5-fluorouracil (5-FU) and its metabolites within a tumor over time. By measuring the 5-FU trapping, it is possible to determine the tumor response at the earliest stage of treatment (before changes in tumor size are observable). In this work, we present preliminary results of detecting the presence and absence of 5-FU trapping in mice bearing H-508 and HT-29 colorectal tumors, respectively.

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