Abstract #3981

Effect of DRD4 receptor −616 C/G polymorphism on thalamic GABA levels in pediatric primary nocturnal enuresis patients

Yi You¹, Zijun Li¹, Xiaoqi Wang², and Bing Yu¹

¹Shengjing Hospital of China Medical University, Shenyang, China, ²Philips Healthcare China, Beijing, China

The objective of this study is to explore the effect of DRD4 −616 C/G single nucleotide polymorphism (SNP) on thalamic GABA levels in with primary nocturnal enuresis (PNE). Results indicates the DRD4 −616 C allele is associated with increased thalamic GABA levels and higher arousal from sleep (AS) scores in PNE children. This research helps us understand the genetic susceptibility of the DRD4 −616 C allele to PNE.

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