Abstract #3974

Multi-Step Frequency-and-Phase Correction for Multiplexed Edited MRS Data

Mark Mikkelsen^1,2, Muhammad G. Saleh^1,2, Jamie Near³, Kimberly L. Chan^1,2,4, Tao Gong⁵, Ashley D. Harris⁶, Georg Oeltzschner^1,2, Nicolaas A. J. Puts^1,2, Kim M. Cecil⁷, Iain D. Wilkinson⁸, and Richard A. E. Edden^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, QC, Canada, ⁴Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Shandong Medical Imaging Research Institute, Shandong University, Jinan, China, ⁶Department of Radiology, University of Calgary, Calgary, AB, Canada, ⁷Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ⁸Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom

Multiplexed edited MRS – more than one edited experiment combined in a single acquisition – involves acquiring subspectra with four or more distinct signal profiles. This technique therefore requires a tailored approach for correcting frequency and phase errors associated with participant head motion and scanner instability. Here, we demonstrate a novel alignment algorithm, termed multi-step frequency-and-phase correction (msFPC), designed to deal with the challenges of aligning individual transients in multiplexed edited data. Testing this method on simulated and in vivo datasets, msFPC was found to outperform other previously demonstrated algorithms (spectral registration and spectral registration with post hoc choline-creatine alignment).

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