Abstract #3969

Towards repeatable GABA-MRS of the hippocampus: Development of an extended post-processing pipeline

Yannik Völzke¹, Eberhard D. Pracht¹, Elke Hattingen², and Tony Stöcker^1,3

¹German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, ²Neuroradiology, Radiology, University Clinic Bonn, Bonn, Germany, ³Department of Physics and Astronomy, University Bonn, Bonn, Germany

The low concentration and the overlap with more prominent resonances hamper the GABA quantification via MR spectroscopy. Strong B0 inhomogeneities in the hippocampus further impede reliable spectroscopic measurements.

To increase the repeatability of the GABA quantification we developed a post-processing module for MEGA-sLASER measurements.The development of an optimized post-processing module reduces the coefficient of variation of the intra-session GABA/creatine signal ratio to (5-10)%. This is essential for clinical trials.

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