Abstract #3966

Non-water Suppressed GABA Edited Magnetic Resonance Spectroscopic Imaging using Density Weighted Concentric Rings k-space Trajectory

Uzay E Emir¹, Pingyu Xia¹, Xiaopeng Zhou¹, Mark Chiew², Adam Steel^3,4, M Albert Thomas⁵, and Ulrike Dydak^1,6

¹School of Health Sciences, Purdue University, West Lafayette, IN, United States, ²Wellcome Centre for Integrative Neuroimaging, FMRIB Division, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ³Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, ⁴National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States, ⁵Department of Radiological Sciences, University of California, Los Angeles, CA, United States, ⁶Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States

In this study, we have developed and demonstrated a non-water suppressed GABA editing Magnetic Resonance Spectroscopic Imaging technique using density-weighted concentric rings k-space trajectory that performs robustly within a clinically feasible acquisition time at 3T. The method has been validated in a series of phantom experiments and its feasibility assessed in a healthy volunteer with a high in-plane resolution of 7.5 × 7.5 mm². Experiments qualitatively demonstrate the advantage of the proposed method in terms of its improved resolution and reduced contamination of spectra from neighboring voxels.

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