Abstract #3961

Simultaneous edited MR spectroscopy of glutathione and macromolecule-suppressed GABA

Georg Oeltzschner^1,2, Kimberly L. Chan^1,2,3, Muhammad G. Saleh^1,2, Mark Mikkelsen^1,2, Nicolaas A. J. Puts^1,2, and Richard A. E. Edden^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

γ-aminobutyric acid (GABA) and glutathione (GSH) can be simultaneously measured in the human brain in vivo at 3T using Hadamard encoding and reconstruction of MEGA-edited spectroscopy (HERMES). A drawback of conventional HERMES of GABA/GSH is the contamination of the edited GABA peak with co-edited macromolecular signals (MM), reducing the specificity of the method. We propose the addition of symmetrical suppression into the HERMES framework, and demonstrate the successful implementation of this approach in ten healthy subjects.

This abstract and the presentation materials are available to members only; a login is required.

Join Here