Stabilized micelles have shown prolonged blood circulation and targeting to solid tumors through enhanced permeability and retention (EPR) effect. It has been demonstrated that Intezyne's Versatile Encapsulation and Crosslinking Technology (IVECT™) has the advantage of allowing the micelles to be crosslinked via a pH-sensitive Fe(III) metal coordination reaction that permeates xenografted tumors and clears from circulation without retention in the kidneys or liver. In this work we developed a theragnostic method to study drug delivery over time of IVECT by T1-weighted image histogram and image intensity in the tumor, kidneys, liver and muscle in a HCT116 Xenograft Model.
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