Pharmacokinetic models for perfusion quantification with DCE-MRI using a low-molecular-weight contrast agent (LMCA) in skeletal muscle of pigs were validated. This in vivo study included compartmental and distributed parameter models which allow estimation of the functional and structural composition of heterogeneously perfused tissues. The different tracer kinetic models, which measure transport parameters in physically meaningful units in heterogeneous tissue, were compared to identify a method that allows reliable quantitative determination of physiological parameters. Double-contrast agent DCE-MRI using LMCA and intravascular CA in combination with the 2-compartment exchange model extended by a nonnutritive arteriolar compartment yields the most reliable results.
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