Abstract #3916

Oxygen-Enhanced MRI for the Detection of Hypoxia in Patients with Head and Neck Cancer

Rafal Panek^1,2, Kee H. Wong^3,4, Liam Welsh^3,4, Angela M. Riddell³, Dow-Mu Koh^3,4, Veronica Morgan³, Shreerang A. Bhide^3,4, Kevin J. Harrington^3,4, Christopher M. Nutting³, Maria Schmidt^3,4, Martin O. Leach^3,4, James P.B. O’Connor^5,6, Kate L. Newbold³, and Simon P. Robinson⁴

¹Nottingham University Hospitals, Nottingham, United Kingdom, ²University of Nottingham, Nottingham, United Kingdom, ³The Royal Marsden NHS Foundation, London, United Kingdom, ⁴The Institute of Cancer Research, London, United Kingdom, ⁵The University of Manchester, Manchester, United Kingdom, ⁶Christie NHS Foundation Trust, Manchester, United Kingdom

Tumour hypoxia is a recognized cause of treatment failure. Noninvasive methods to quantify distribution and extent of hypoxia remain an unmet clinical need. Quantitation of the longitudinal relaxation rate, R₁, using oxygen-enhanced MRI (OE-MRI), can be used to monitor differences in levels of paramagnetic molecular oxygen in plasma. In this study, we report a significantly reduced hyperoxia-induced ΔR₁ response in HNSCC in comparison to the healthy lymph nodes, revealed by OE-MRI. Such a reduction can be attributed to regions of impaired tumour vasculature and hypoxia, the presence of which may be linked to a poorer outcome.

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