Abstract #3909

Correlations Between Brain Structural Volumes and Brain Metabolite Concentrations in Alzheimer’s Disease: Preliminary Results from the NeuroMet Project

Ariane Fillmer¹, Theresa Köbe², Semiha Aydin¹, Laura Goeschel², Agnes Flöel^2,3, Florian Schubert¹, and Bernd Ittermann¹

¹Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany, ²Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ³Department of Neurology, University Medicine Greifswald, Greifswald, Germany

The NeuroMet project aims to identify new biomarkers for Alzheimer’s disease (AD) and to reduce measurement uncertainties for known biomarkers for AD. This work presents first NeuroMet results with a focus on ultra-high field MR imaging and MR spectroscopy. Significant correlations were found between volumes of cortical and subcortical gray matter structures and concentrations of NAA, glutamate and GABA.

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