Abstract #3907

Metabolic basis of (de)activation fMRI paradigms: J-edited lactate and diffusion-weighted water 1H-MRS

Yury Koush¹, Robin A. de Graaf¹, Ron Kupers², Laurence Dricot³, Douglas L. Rothman¹, and Fahmeed Hyder¹

¹MRRC, Yale University, New Haven, CT, United States, ²Department of Clinical Neurophysiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, ³Institute of Neuroscience, University of Louvain, Brussels, Belgium

During task-based versus rest epochs, the BOLD signal increases in a task-positive region (activation paradigm) and decreases in a task-negative region (deactivation paradigm), also known as the default mode network (DMN). We investigated the metabolic basis of (de)activation paradigms using concurrent ¹H-MRS acquisitions of J-edited lactate and diffusion-weighted water. Using (de)activation paradigms, we detected associated increase of water (i.e., BOLD signal) and lactate in visual cortex (non-DMN area), whereas in posterior cingulate cortex (DMN area) water decreased but lactate did not change. These results suggest similar degrees of aerobic glycolysis in both DMN and non-DMN areas.

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