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Abstract #3902

Stress Induced bioenergetic perturbations in CMS rat model of Depression – An invivo phosphorousMRS study at 7T.

Hemanth Kumar B S1, Dinesh K Deelchand2, Sushanta Kumar Mishra1, Sadhana Singh1,3, and Subash Khushu1

1NMR Research Centre, DRDO-INMAS, New Delhi, India, 2Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, United States, 3Department of Anesthesiology, University of California Los Angeles, Los Angeles, CA, United States

A chronic mild stress (CMS) animal model for depression was developed and validated using behavioural studies like OFT, FST and SCT. Following anaesthesia, invivo Phosphorous MRS was acquired covering the entire brain using ISIS pulse sequence at field strength of 7T. The spectra thus acquired were processed using LC-model for bioenergy metabolites quantification. The overall study provides new evidence on brain energy related metabolites and redox balance in CMS rats as compared to controls, suggesting that compromised energy metabolism and altered NAD biology observed in CMS rats. The study also revealed changes in High energy phosphate metabolites and membrane phospholipids.

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