Abstract #3894

Partial Normalization of altered brain acetate metabolism in alcohol-dependent subjects after one month of sobriety

Lihong Jiang¹, Gustavo A. Angarita², Kevin L. Behar², Elizabeth Guidone¹, Barbara I. Gulanski³, Stuart A. Weinzimer⁴, Robin A. de Graaf¹, and Graeme F. Mason^1,2

¹Diagnostic Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, ²Psychiatry, Yale University, New Haven, CT, United States, ³Yale Health, Yale University, New Haven, CT, United States, ⁴Pediatrics, Yale University, New Haven, CT, United States

The purpose of this study is to analyze the adaptation of brain acetate metabolism of AD subjects upon detoxification in order to understand the mechanism of alcohol addiction. Using 13C-magnetic resonance spectroscopy in combination of 2-13C-acetate infusion, and monitor the turn over rates of brain 13C-labeled glutamate/glutamine neurotransmitter, we have found increased brain acetate metabolism after detoxification treatment, suggesting the compromised acetate uptake/metabolism in AD subjects.

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