The goal of this study was to compare the apparent transverse relaxation time constants (T2) of metabolites obtained in young and older subjects in three brain regions (occipital cortex (OCC), posterior cingulate cortex (PCC) and prefrontal cortex (PFC)) using LASER at 3T. A lower apparent T2s of N-acetyl aspartate and tissue water were measured in older adults in all three regions. T2 for total creatine and myo-inositol were also shorter in older adults in OCC and PCC. In conclusion, differences in T2 values of metabolites during normal brain aging are region-dependent.
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