Abstract #3883

In vivo 31P MRI at 7 Tesla in humans using a 3D spectrally selective SSFP sequence and TPI k-space sampling.

Arthur Coste¹, Sandro Romanzetti², Denis Le Bihan¹, Cécile Rabrait-Lerman¹, and Fawzi Boumezbeur¹

¹DRF-ISVFJ-NeuroSpin, CEA, Paris Saclay University, Gif sur Yvette, France, ²Neurology Department, RWTH Aachen University Hospital, Aachen, Germany

Spectrally selective ³¹P MRI can be of interest for the study of brain energetics for clinical research. Using a 3D SSFP sequence with non-Cartesian Twisted Projection Imaging sampling, we obtained whole-brain images of ATP and PCr in healthy volunteers at 7 Tesla with a higher normalized SNR than with CSI. Local concentration quantification was performed using the phantom replacement approach after accounting for the T₁/T₂-weighting and the transmission and reception profiles of our coil yielding consistent results.

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