Abstract #3879

Minimum echo-time PRESS-localized proton observed carbon edited (POCE) magnetic resonance spectroscopy for rat brain imaging using simultaneous editing and localization pulses.

Chathura Kumaragamage¹, Dan Madularu², Axel P Mathieu³, Derek Lupinsky³, Robin A de Graaf⁴, and Jamie Near²

¹Biomedical Engineering, McGill University, Montreal, QC, Canada, ²McGill University, Montreal, QC, Canada, ³Douglas Hospital Brain Imaging Center, Montreal, QC, Canada, ⁴Yale University, New Haven, CT, United States

Dynamic Carbon-13 (¹³C) magnetic resonance spectroscopy (MRS) remains to be the only noninvasive method capable of measuring neuroenergetics and neurotransmitter cycling in the brain¹. Proton observed carbon edited (POCE) MRS² is an attractive alternative to direct ¹³C methods due to improved signal-to-noise-ratio (SNR). This study reports a PRESS localized POCE sequence utilizing simultaneous editing and localization (SEAL-PRESS), which allows the TE to be reduced to a theoretically optimal value of ~1/J_HC (8.1ms, in this implementation). The sequence was validated in phantom and in a rat preparation, and demonstrated >17% improvement in ¹³C labeled metabolites relative to a 12.6-ms PRESS-POCE sequence.

This abstract and the presentation materials are available to members only; a login is required.

Join Here