Abstract #3873

Influence of motion and partial volume effects on measured tissue sodium concentration in cardiac $$$^{23}$$$Na MRI

Johanna Lott¹, Jonathan M. Lommen¹, Sebastian C. Niesporek¹, Tanja Platt¹, Nicolas G.R. Behl¹, Mark E. Ladd¹, and Armin M. Nagel^1,2

¹Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany

Sodium (²³Na) ions are involved in many biological processes. The tissue sodium concentration can be determined with ²³Na MRI; however, fast relaxation times, breathing and heart motion as well as the high sodium concentration of blood render quantitative determination of the myocardial sodium concentration challenging. We present a method to analyze the tissue sodium concentration within the myocardium by utilizing a partial volume correction as well as correction of motion effects. The presented workflow can reduce the bias by up to 49%.

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