Abstract #3862

High resolution 3D EPSI Spectroscopic Imaging compared with Spectral Localization by Imaging (SLIM)

Sean Edmund Ellis^1,2, Peter Adany¹, Phil Lee^1,2,3, and In-Young Choi^1,2,3,4

¹Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States, ²Department of Bioengineering, University of Kansas, Lawrence, KS, United States, ³Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States, ⁴Department of Neurology, University of Kansas Medical Center, Kansas City, KS, United States

Quantitative measurements of metabolites in important structures in the human brain are challenging to acquire using conventional spectroscopic imaging methods. In this study, we compared regional metabolite concentrations obtained from high resolution 3D EPSI MRSI data using two different methods: spatial averaging inside regions of interest using the MIDAS software, and Spectral Localization by Imaging (SLIM)-based MRS. Deep brain structures were studied and compared using the two methods. The quantitative outcomes of 3D EPSI and SLIM were comparable and SLIM could provide metabolite concentrations using shorter scan times by reducing the required number of voxel acquisitions.

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