Abstract #3842

Arbitrary Variable Density (AVD)-GRAPPA Enabled EPSI of Short-echo 3D H1-MRSI

Maryam Vareth^1,2, Yan Li¹, Misung Han¹, Marram P. Olson¹, Jason Crane¹, Sarah J. Nelson^1,3, and Janine M. Lupo^1,3

¹Surbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Berkeley Institude of Data Science, Univeristy of Califonia, Berkeley, Berkeley, CA, United States, ³UCSF/UCBerkeley Joint Graduate Group in Bioengineering, San Francisco, CA, United States

This work investigates the feasibility of using arbitrary sampling patterns and GRAPPA-EPSI reconstruction to shorten the acquisition time and increase the spatial resolution of short-echo 3D-MRSI for routine clinical purposes. Fully sampled data were retrospectively under-sampled to achieve effective acceleration rates of 2, 3 and 4 using a variety of sampling patterns. The modified GRAPPA algorithm: 1) took advantage of the FID time points, 2) handled arbitrary sampling patterns, and 3) used a fast, high-resolution external calibration acquisition to estimate sensitivity maps.

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