Abstract #3838

Levels of choline-containing compounds are not increased in human liver metastases of colorectal cancer: an assessment by 1H MR spectroscopy

Edwin E.G.W. ter Voert^1,2, Linda Heijmen ², Jack J.A. van Asten ², Alan J. Wright ³, Iris D. Nagtegaal ⁴, Cornelis J.A. Punt ⁵, Johannes H.W. de Wilt⁶, Hanneke W.M. van Laarhoven ^5,7, and Arend Heerschap ²

¹Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland, ²Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ³Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, ⁴Pathology, Radboud University Medical Center, Nijmegen, Netherlands, ⁵Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁶Surgery, Radboud University Medical Center, Nijmegen, Netherlands, ⁷Medical Oncology, Radboud University Medical Center, Nijmegen, Netherlands

The commonly observed relative signal increase of choline-containing compounds (tCho) in ¹H MR spectra of tumors may serve as a diagnostic biomarker. Here we evaluate the potential of this tCho signal in ¹H MR spectra of the human liver to assess metastases of colorectal cancers. An increased tCho signal was not observed for these metastases. With increasing tumor volumes, the tissue levels of tCho decreased. The likely reason is a larger necrotic voxel fraction as it correlated with more higher ADC values assessed by diffusion weighted imaging. A Bland-Altman analysis revealed average repeatability in normal livers and poor repeatability in tumors.

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