Abstract #3822

The effect of flow suppression on BOLD MRI of lung tumor

Heling Zhou¹, Olivier Belzile², Zhang Zhang³, Jo Wagner¹, Chul Ahn⁴, James Richardson⁵, Debabrata Saha³, Rolf A Brekken⁶, and Ralph P Mason¹

¹Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ²Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, United States, ³Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, United States, ⁴Clinical Science, UT Southwestern Medical Center, Dallas, TX, United States, ⁵Pathology, UT Southwestern Medical Center, Dallas, TX, United States, ⁶Surgery, UT Southwestern Medical Center, Dallas, TX, United States

Blood oxygen level dependent (BOLD) MRI is used to provide information on tumor oxygenation. However, the measurements are susceptible to blood flow changes, which often occur during hyperoxic gas challenge. This study investigated the extent of flow sensitivity by comparing BOLD measurements with and without flow suppression using two orthotopic lung xenograft tumor models. Flow suppression was found to affect multiple measurements including ΔSI(%) and R₂*. The range of discrepancy was smaller in R₂* than the ΔSI(%). High similarity was found in spatial patterns. ROI and spatial pattern analysis showed higher sensitivity to flow in A549 tumors than H460 tumors.

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