Abstract #3813

Changes in Apparent Diffusion Coefficient (ADC) of the Dominant Tumor during Dose-Painted Radiotherapy and High Dose Rate (HDR) Brachytherapy for Prostate Cancer

Sangjune Lee¹, Jenny Lee¹, Tim Craig¹, Alejandro Berlin¹, Peter Chung¹, Cynthia Ménard², and Warren Foltz¹

¹Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, ²Radiation Oncology, University of Montreal, Montreal, ON, Canada

PIRADS-2 compliant Apparent Diffusion Coefficient mapping (ADC) and T2-weighted imaging was performed at baseline and week 6 of radiotherapy in 57 patients with localized prostate cancer. 101 radiomics features were calculated across the gross tumor volume (GTV) and whole prostate (WP). GTV ADC histogram metrics (10 percentile, median, mean) increased (p<1e-06) at equivalent maximum ADC values. High percentile WP ADC histogram metrics (90 percentile, maximum) decreased (p<2e-05) at equivalent 10 percentile/median/mean values. Between 44 (for GTV ADC) and 65 (for WP applied to T2w-weighted images) radiomics features were significantly different and will be explored as potential early predictive biomarkers of response.

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