Abstract #3811

Susceptibility-based positive contrast for visualization and localization of implanted brachytherapy seeds in realistic prostate phantoms

Reyhaneh Nosrati^1,2, Matt Wronski^3,4, Ananth Ravi^1,2,3,4, Ana Pejović-Milić¹, Gerard Morton^5,6, and Greg Stanisz^1,3,4

¹Medical Physics, Ryerson University, Toronto, ON, Canada, ²Sunnybrook Research Institute, Toronto, ON, Canada, ³Medical Physics, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁴Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁵Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁶Radiation oncology, University of Toronto, Toronto, ON, Canada

Employing susceptibility-based positive contrast for depiction and localization of closely implanted elongated paramagnetic objects (i.e. brachytherapy seeds) is very challenging due to the orientation dependence and/or size overestimation of reconstructed object. In this study, 321 brachytherapy seeds were implanted in four realistic prostate phantoms; all phantoms were scanned at three different angles on a 1.5T MR scanner. A novel susceptibility-based workflow was proposed for visualization and localization of the seeds. For all scanning angles the reconstructed seed shapes, centroids and orientations were identical and no significant difference was found between the proposed method and the current clinically used CT-based method.

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