Abstract #3799

Longitudinal response monitoring in experimental prostate tumors by DCE-MRI after C-12 ion and photon radiotherapy

Alina Leandra Bendinger¹, Christian Peter Karger^2,3, Charlotte Debus⁴, Ralf Omar Floca^3,5, Jürgen Debus^3,6, Jörg Peter¹, and Christin Glowa^2,3,6

¹Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ³Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany, ⁴Translational Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁵Division of Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁶Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany

Dynamic contrast-enhanced MRI was used for the longitudinal monitoring of two well characterized experimental prostate tumors (Dunning R3327-AT1 and -HI) after isodose and isoeffective radiotherapy. The effect of carbon (¹²C)-ion irradition compared to photons on tumor vasculature was characterized by non-compartmental analysis and pharmacokinetic modelling employing the extended Tofts model. Isodose and isoeffective irradiation experiments indicated that the beam modality has a stronger effect on tumor perfusion and permeability than the dose. While changes in perfusion were identified for the highly undifferentiated AT1-tumor, the more differentiated HI-tumor showed only minor changes in perfusion upon irradiation.

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