Abstract #3782

Associations between tissue sodium concentration, age and cross-sectional area in the healthy spinal cord

Bhavana Shantilal Solanky¹, Ferran Prados², Marios C Yiannakas¹, Vanessa Bassan¹, Baris Kanber², Sebastien Ourselin², Olga Ciccarelli¹, and Claudia Angela Gandini Wheeler-Kingshott^1,3,4

¹Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, ²Translational Imaging Group, Centre for Medical Image Computing (CMIC), Department of Medical Physics and Bioengineering, University College London, London, United Kingdom, ³Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ⁴Brain MRI 3T Research Centre, C. Mondino National Neurological Institute, Pavia, Italy

Tissue sodium concentration has recently come into the spotlight for a number of neurological conditions, given its potential role in neurodegeneration and due to the advances in MRI technology. This has led to many studies in the brain, but there is a shortage of studies characterising sodium in the spinal cord. Here we use ²³Na-MRS to measure sodium in the healthy spinal cord and look at the association between tissue sodium concentrations with age and spinal cord cross sectional area.

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