Abstract #3775

Pitfall of synthetic MRI: Effect of gadolinium on the estimation of brain tissue volumes and myelin based on rapid simultaneous relaxometry

Tomoko Maekawa^1,2, Akifumi Hagiwara^1,2, Masaaki Hori¹, Koji Kamagata¹, Christina Andica¹, Takuya Haruyama^1,3, Kanako Sato¹, Saori Koshino^1,2, Ryusuke Irie^1,2, Akihiko Wada¹, and Shigeki Aoki¹

¹Radiology, Juntendo University, Tokyo, Japan, ²Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ³Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan

We investigated the effect of gadolinium on the automatic tissue and myelin volumetry using synthetic MRI. 17 patients with metastases and 19 patients without metastasis were retrospectively analyzed before and after administration of gadolinium. After gadolinium administration, white matter volume (ml), non-white matter/gray matter/cerebrospinal fluid volume (ml), myelin volume (ml), and myelin volume/brain parenchymal volume (%) were significantly increased, whereas gray matter volume (ml), cerebrospinal fluid volume (ml), brain parenchymal volume (ml), and intracranial volume (ml) were significantly decreased regardless of metastasis. The gadolinium had significant effects on the automatic calculation of tissue and myelin volumes estimated by synthetic MRI.

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