Abstract #3756

Non-Invasive Imaging of Brain Clearance Pathways using Multiple Echo Time ASL: An Aquaporin-4 Study

Yolanda Ohene¹, Ian F Harrison ¹, Payam Nahavandi ¹, Ozama Ismail ¹, Ole P Ottersen ², Erlend A Nagelhus³, David L Thomas ^4,5, Mark F Lythgoe ¹, and Jack A Wells ¹

¹UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, United Kingdom, ²Karolinska Institutet, Stockholm, Sweden, ³University of Oslo, Oslo, Norway, ⁴Neuroradiological Academic Unit, UCL Institute of Neurology, University College London, London, United Kingdom, ⁵Leonard Wolfson Experimental Neurology Centre, UCL Institute of Neurology, University College London, London, United Kingdom

We have developed the first non-invasive technique that is able to detect changes in brain AQP4-mediated clearance pathways. Our multi-TE ASL technique measures the exchange of vascular water into cortical brain tissue of mouse brain. We report a significant increase in the cortical exchange time between WT (377 ± 89ms) and AQP4-deficient (536 ± 92ms) mice. While measured CBF, ADC and δ_adid not detect differences, suggesting preserved haemodynamic and energetics between groups. This highlights the novelty of the technique being targeted method to assess water transport in brain clearance pathways, to help better understand neurodegenerative diseases.

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