Abstract #3752

Apolipoprotein E e4 allele is associated with higher structural brain changes in patients with mild cognitive impairment

Sheema Hashem¹, Santosh K Yadav¹, Asma Al-Sulaiti¹, Ajaz A Bhat¹, Tooba Ahmed², Deepak Kaura³, Ari Borthakur⁴, and Mohammad Haris ¹

¹Division of Translational Medicine,Research Branch, Sidra Medicine, Doha, Qatar, ²American School, Doha, Qatar, ³Diagnostic Imaging, Sidra Medicine, Doha, Qatar, ⁴Center for Magnetic Resonance and Optical Imaging, Radiology, University of Pennsylvania, Philadelphia, PA, United States

The aim of this study was to measure the difference in cortical thickness, subcortical volume and CSF biomarkers between MCI patients who carry or lack ApoE ε4 allele. High-resolution T1-weighted images were used for the measurement of cortical thickness and subcortical volume using FreeSurfer. MCI patients who carry ApoE ε4 showed significant reduction in cortical thickness and subcortical volume in multiple brain regions than non-carriers. This suggests that having an ApoE ε4 allele could be a risk factor for the larger tissue damage in the brain of MCI, and these patients may have higher chance of developing Alzheimer’s or other dementia.

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