Abstract #3750

In-vivo mapping of monoaminergic network disruption in Alzheimer’s disease: implications for neuropsychiatric symptoms

Laura Serra¹, Marcello D'Amelio², Carlotta Di Domenico¹, Camillo Marra³, Nicola Biagio Mercuri⁴, Carlo Caltagirone⁵, Mara Cercignani^1,6, and Marco Bozzali^1,6

¹Neuroimaging Laboratory, Santa Lucia Foundation IRCCS, Rome, Italy, ²Laboratory Molecular Neurosciences, Santa Lucia Foundation IRCSS, Rome, Italy, ³Institute of Neurology, Catholic University, Rome, Italy, ⁴Laboratory of Experimental Neurology, Santa Lucia Foundation IRCCS, Rome, Italy, ⁵Department of Clinical and Behavioural Neurology, Santa Lucia Foundation IRCCS, Rome, Italy, ⁶Department of Neuroscience, Brighton & Sussex Medical School, Brighton, United Kingdom

Some recent animal models and neuropathological evidence highlighted the loss of noradrenergic neurons in the locus coeruleus and dopaminergic neurons in the ventral tegmental area (VTA) as important pathophysiological events in Alzheimer's disease. Here we use resting-state functional MRI to show reductions in VTA connectivity in patients with Alzheimer's disease and mild cognitive impairment, which are more prominent in patients with neuropsychiatric symptoms.

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