Abstract #3742

Initial Experience of Cerebral Quantitative Susceptibility Mapping in the HIV Neurocognitive Disorder

Sara Marie Dupont¹, Yan Li², Ycheng Chen^2,3, Janine Lupo², Felicia Chow⁴, and Jared Narvid¹

¹Department of Radiology and Biomedical Imaging, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA, United States, ²Surbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ³Graduate program in BIoengineering, University of California Berkeley and University of California San Francisco, San Francisco, CA, United States, ⁴Department of Neurology, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA, United States

This study investigates the patterns of tissue susceptibility within brains of older HIV+ participants using quantitative susceptibility mapping (QSM) as marker of iron deposition in the brain. Four HIV+ participants and one healthy control were recruited, and QSM and T1w (for cortical parcellation) data were acquired on a 3T MRI scanner. Comparison of QSM values by brain region for each HIV+ participant with the control shows a pattern of increased susceptibility in frontal regions, especially in the frontal medial and subcallosal cortices. Although these results warrant further investigation in a larger cohort, this is the first study investigating changes in QSM in the HIV+ population.

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