Radiological Imaging of Brain Iron Deposits and T1 quantification feasibility using 3D UTE Cones.
Piotr Wielopolski1, Elene vroegindeweij2, Agnita Boon3, Janneke Langendonk2, and Juan Antonio Hernandez-Tamames1
1Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands, 2Porphyria Center Rotterdam, Center for lysosomal and metabolic disease, Erasmus MC, Rotterdam, Netherlands, 3Neurology, Erasmus MC, Rotterdam, Netherlands
In this work, we demonstrate that 3D UTE cones enables the possibility of T1 contrast and T1 relaxometry of iron deposits in the brain. We present radiological images of brain iron and T1 quantification of iron deposits in a pathology with an exacerbated amount of iron in the brain. We demonstrate that even for conventional T2 and T2* mapping is challenging to obtain relaxometry. However, it is feasible for a 3D UTE cones sequence.
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