This study applied 13C MR metabolic imaging with hyperpolarized [1-13C]pyruvate for the differential characterization of metabolic profiles between enhancing and non-enhancing brain tumors. The levels of lactate, which was normalized by vascular total carbon signal, were significantly different between the contralateral brain, non-enhancing and enhancing tumor, while the levels of pyruvate were similar between these three tissues. The results from this study suggested that this technique may be useful in distinguishing functional characteristics between normal brain tissue and heterogeneous anatomical lesions in brain tumors.
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