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Abstract #3708

Evaluating hyperpolarized lactate as a theranostic agent for stroke

Jean-Noël Hyacinthe1,2, Lara Buscemi3, Mario Lepore4, Rolf Gruetter4,5,6,7, Lorenz Hirt3, and Mor Mishkovsky5

1School of Health Sciences - Geneva, University of Applied Sciences and Arts Western Switzerland, Geneva, Switzerland, 2Image Guided Intervention Laboratory, Faculty of Medicine, University of Geneva, Geneva, Switzerland, 3Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, 4Centre d'Imagerie Biomédicale (CIBM), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 5Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 6Department of Radiology, University of Geneva, Geneva, Switzerland, 7Department of Radiology, University of Lausanne, Lausanne, Switzerland

Stroke is the leading cause of disability and the third leading cause of death worldwide. Lactate administration into the ischemic brain directly after blood reperfusion was found to be neuroprotective. MR with hyperpolarized (HP) probes enables in vivo real-time measurement of biochemical transformations of HP 13C-labeled precursors, including lactate. The aim of this study was to demonstrate the feasibility of probing HP [1-13C]L-lactate metabolism in mice brain after ischemic stroke, and to study the influence of the time window after reperfusion on its conversion in order to evaluate the potential of HP lactate as a theranostic agent for stroke.

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Abstract