Abstract #3706

Pulmonary Metabolism and Inflammation During Mechanical Ventilation: A Hyperpolarized Carbon-13 Study

Mehrdad Pourfathi¹, Shampa Chatterjee², Maurizio Cereda³, Yi Xin¹, Stephen Kadlecek¹, Hooman Hamedani¹, Ian Duncan¹, Sarmad Siddiqui¹, Harrilla Profka¹, Kai Ruppert¹, Luis Loza¹, Faraz Amzajerdian¹, Ryan Baron¹, Mary Spencer¹, Tahmina Achekzai¹, and Rahim R. Rizi¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Physiology, University of Pennsylvania, Philadelphia, PA, United States, ³Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States

We showed that secondary inflammation due to atelectasis increases pulmonary anaerobic metabolism (lactate-to-pyruvate ratio). Recruitment with PEEP limits anaerobic metabolism and contains injury progression. Measuring tissue metabolism with hyperpolarized MRI can disclose novel pathways of tissue damage during lung injury and assess secondary injury progression in ventilated lungs.

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