Abstract #3694

Gadolinium complexes conjugated with nonsteroidal anti-inflammatory drugs (NSAIDs) as potential inflammation targeting MRI contrast agents.

Heekyung Kim^1,2, Bokyung Sung³, Soyeon Kim³, Garam Choi³, Ah Rum Baek³, Md Kamrul Islam³, Taekwan Lee⁴, DongKyu Kim⁴, Hoe Su Jung⁴, and Yongmin Chang^2,3,5

¹Department of Molecular Medicine & BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Republic of Korea, ²Institute of Biomedical Engineering Research, Kyungpook National University, Daegu, Republic of Korea, ³Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Republic of Korea, ⁴Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea, ⁵Department of Radiology, Kyungpook National University, Daegu, Republic of Korea

Inflammation targeting MR CAs conjugated with NSAIDs were prepared according to the general synthetic methods, and characterized by spectroscopic analysis. The relaxivities of theses gadolinium complexes are slightly higher than those of Gadovist®. From in vivo T₁-weighted MR images, strong enhancement was observed in the inflammatory region. Also our new gadolinium complexes represent high kinetic inertness in chemically competitive environment compared with other clinically used MR CAs.

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