Simultaneous hyperpolarized 13C-pyruvate MRI and 18F-FDG PET imaging have the several potential applications, especially for understanding the complex metabolic processes of cancer. However, we hypothesized the relatively high concentrations of 13C-pyruvate used in hyperpolarized MRI could interfere with the 18F-FDG uptake when administrated simultaneously, because their metabolic products compete for the same pathways. In this study, we examined the effect of injected pyruvate and lactate on 18F-FDG uptake in healthy rats and in rats with implanted C6 gliomas, and discuss the metabolic interactions observed.
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