Abstract #3688

CSF transport of 18F and 18FDG via the brain-wide glymphatic pathway visualized by Integrative PET-MRI

Helene Benveniste¹, Hedok Lee¹, Michael Budassi², S. David Smith³, Mark Schweitzer⁴, Nora Volkow⁵, Maiken Nedergaard⁶, and Paul Vaska⁴

¹Anesthesiology, Yale School of Medicine, New Haven, CT, United States, ²Biomedical Engineering, Stony Brook Medicine, Stony Brook, NY, United States, ³SAII, Stony Brook, NY, United States, ⁴Radiology, Stony Brook Medicine, Stony Brook, NY, United States, ⁵NIAAA, Bethesda, MD, United States, ⁶University of Copenhagen, Copenhagen, Denmark

The glymphatic pathway was recently re-discovered as a CSF transport system for brain waste removal. The peri-vascular space functions as the ”front end” for toxic waste clearance via the ‘glymphatic pathway. To facilitate future translation to the clinic we executed experiments to map glymphatic transport in the live rodent brain using dynamic integrated MRI-PET imaging in combination with CSF administration of a paramagnetic contrast agent and two different 18F-labeled radioisotopes.

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