Abstract #3676

Including bone in DIXON-based PET/MRI attenuation correction for primary and recurrent prostate cancer

Mattijs Elschot¹, Kirsten M Selnæs^1,2, Håkon Johansen³, Brage Krüger-Stokke^1,3, Helena Bertilsson^4,5, and Tone F Bathen^1,2

¹Department of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Trondheim, Norway, ²St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway, ³Department of Radiology and Nuclear Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway, ⁴Department of Urology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway, ⁵Department of Cancer Research and Molecular Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway

Accurate correction for bone attenuation may be important for PET/MRI of prostate cancer due to the high bone-density of the pelvis. In this study we evaluated a previously proposed method that includes bone attenuation coefficients in the DIXON-based attenuation map by co-registration with an atlas of the major bones in the body. We found that the inclusion of bone significantly increased the standardized uptake values of soft tissue lesions, but the effect was only in the order of 3%. In addition, we observed that bone registration errors were present near 31% of the lesions, which may hamper widespread clinical applicability.

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