BOLD functional magnetic resonance imaging (fMRI) provides crucial information about the large-scale organisation and function of the healthy and diseased brain. Despite its widespread use, identifying the neuronal-basis for specific functional imaging-based signatures, identified in human disorders and animal models, remains a mostly unmet challenge. Presently, we combine chemogenetic neuromodulation with whole-brain resting-state mouse fMRI and tissue clearing, to reveal both the functional contribution and spatial localization of a targeted neuronal population on resting-state functional connectivity. This approach enables researchers to examine the functional role played by selected neuronal populations on distributed neuronal networks.
This abstract and the presentation materials are available to members only; a login is required.