Abstract #3650

The Protective Effects of Ultramicronized Palmitoylethanolamide on the glutamatergic system in a triple transgene mouse model of Alzheimer disease

Rossella Canese¹, Giulia Carpinelli¹, Gianmauro Palombelli¹, Maria Rosaria Brunzuoli², Silvio Calcagnini², Luca Steardo², Tommaso Cassano³, and Caterina Scuderi²

¹Dept. of Cell Biology and neurosciences, Istituto Superiore di Sanita', Rome, Italy, ²Dept. of Physiology and Pharmacology “V. Erspamer”, SAPIENZA University of Rome, Rome, Italy, ³Dept. of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy

We investigate the effects of a chronic treatment with an endogenous lipid mediator palmitoylethanolamide on the onset and progression of AD in 3xTg-AD mice. Behavioural tests showed improvements in learning and memory, and in both the depressive and anhedonia-like phenotype in PEA-treated 3×Tg-AD mice. MRI/MRS in vivo analysis, microdialysis and western blot, RT-PCR, and immunofluorescence show that PEA normalizes astrocytic function, rebalances glutamatergic transmission, and restrains neuroinflammation. The efficacy of PEA is particularly potent in younger mice, suggesting its potential as an early treatment.

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