Abstract #3645

Non-invasive Characterization of the Cerebellar Nuclei in Degenerative Cerebellar Ataxias (SCA3, SCA6) with Quantitative Susceptibility Mapping (QSM) at 3 Tesla

Andreas Deistung^1,2,3, Dominik Jäschke², Sophia L Göricke⁴, Dae-In Chang², Katharina M Steiner², Andreas Thieme², Jens Claaßen², Ellen Uslar², Markus Gerwig², Mark E Ladd^3,5, Jürgen R Reichenbach¹, and Dagmar Timmann²

¹Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Jena, Germany, ²Department of Neurology, Essen University Hospital, Essen, Germany, ³Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany, ⁴Institute of Diagnostic and Interventional Neuroradiology, Essen University Hospital, Essen, Germany, ⁵Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

We investigated non-invasively the cerebellar nuclei of spinocerebellar ataxia type 3 (SCA3) and SCA6 patients by using quantitative susceptibility mapping (QSM) at 3 T. Absolute volumes, relative volumes (with respect to the total intracranial volume), and magnetic susceptibilities of the cerebellar nuclei were found to be significantly lower for the dentate between SCA6 patients and healthy controls but did not significantly differ between SCA3 and healthy controls. Univariate linear correlations of relative nuclei volumes with ataxia rating scales revealed statistically significant correlations for the dentate and globose nuclei in SCA6 but not in SCA3.

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